The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …

Congenital anomalies of the kidney and urinary tract (CAKUT) cover a wide range of
structural malformations that result from defects in the morphogenesis of the kidney and/or …

Tissue-resident immune cells are important for organ homeostasis and defense. The
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …

Acute kidney injury (AKI) is an under-recognized morbidity of neonates; the incidence
remains unclear due to the absence of a unified definition of AKI in this population and …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …

Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 1 in 500 births and
are a major cause of morbidity in children. Notably, CAKUT account for the most cases of …

Naturally-derived biomaterials have been used for decades in multiple regenerative
medicine applications. From the simplest cell microcarriers made of collagen or alginate, to …

The development of the human kidney is a complex process that requires interactions
between epithelial and mesenchymal cells, eventually leading to the coordinated growth …

In the human fetal kidney (HFK) self-renewing stem cells residing in the metanephric
mesenchyme (MM)/blastema are induced to form all cell types of the nephron till 34th week …

Histone deacetylases (HDACs) regulate fundamental biological processes such as cellular
proliferation, differentiation, and survival via genomic and nongenomic effects. This study …