The Outer Membrane Proteins OmpA, CarO, and OprD of Acinetobacter baumannii Confer a Two-Pronged Defense in Facilitating Its Success as a Potent Human …

SR Uppalapati, A Sett, R Pathania - Frontiers in microbiology, 2020 - frontiersin.org
Of all the ESKAPE pathogens, carbapenem-resistant and multidrug-resistant Acinetobacter
baumannii is the leading cause of hospital-acquired and ventilator-associated pneumonia …

The diverse functional roles of elongation factor Tu (EF-Tu) in microbial pathogenesis

KL Harvey, VM Jarocki, IG Charles… - Frontiers in …, 2019 - frontiersin.org
Elongation factor thermal unstable Tu (EF-Tu) is a G protein that catalyzes the binding of
aminoacyl-tRNA to the A-site of the ribosome inside living cells. Structural and biochemical …

Genome-wide phage susceptibility analysis in Acinetobacter baumannii reveals capsule modulation strategies that determine phage infectivity

J Bai, N Raustad, J Denoncourt, T van Opijnen… - PLoS …, 2023 - journals.plos.org
Phage have gained renewed interest as an adjunctive treatment for life-threatening
infections with the resistant nosocomial pathogen Acinetobacter baumannii. Our …

Cell surface-associated protein elongation factor Tu interacts with fibronectin mediating the adhesion of Lactobacillus plantarum HC-2 to Penaeus vannamei intestinal …

Y Du, H Li, W Xu, X Hu, T Wu, J Chen - International Journal of Biological …, 2023 - Elsevier
The adherent colonization of lactic acid bacteria in the animal intestine is the basis for their
probiotic effect, and their bacteria surface proteins play an important role in this process …

Inhibition of diverse DsbA enzymes in multi-DsbA encoding pathogens

M Totsika, D Vagenas, JJ Paxman, G Wang… - Antioxidants & redox …, 2018 - liebertpub.com
Aims: DsbA catalyzes disulfide bond formation in secreted and outer membrane proteins in
bacteria. In pathogens, DsbA is a major facilitator of virulence constituting a target for …

Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors

A Talavera, J Hendrix, W Versées, D Jurėnas… - Science …, 2018 - science.org
Bacterial protein synthesis is intricately connected to metabolic rate. One of the ways in
which bacteria respond to environmental stress is through posttranslational modifications of …

Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein

A Koenigs, PF Zipfel, P Kraiczy - PLoS One, 2015 - journals.plos.org
Acinetobacter baumannii is an important nosocomial pathogen, causing a variety of
opportunistic infections of the skin, soft tissues and wounds, urinary tract infections …

Proteomic Analyses of Acinetobacter baumannii Clinical Isolates to Identify Drug Resistant Mechanism

P Wang, RQ Li, L Wang, WT Yang, QH Zou… - Frontiers in cellular and …, 2021 - frontiersin.org
Acinetobacter baumannii is one of the main causes of nosocomial infections. Increasing
numbers of multidrug-resistant Acinetobacter baumannii cases have been reported in recent …

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

B Mohanty, K Rimmer, RM McMahon, SJ Headey… - PLoS …, 2017 - journals.plos.org
At a time when the antibiotic drug discovery pipeline has stalled, antibiotic resistance is
accelerating with catastrophic implications for our ability to treat bacterial infections. Globally …

DsbA is a redox-switchable mechanical chaperone

EC Eckels, D Chaudhuri, S Chakraborty… - Chemical …, 2021 - pubs.rsc.org
DsbA is a ubiquitous bacterial oxidoreductase that associates with substrates during and
after translocation, yet its involvement in protein folding and translocation remains an open …