Hypoalbuminemia is associated with the acquisition and severity of infectious diseases, and
intact innate and adaptive immune responses depend on albumin. Albumin oxidation and …

The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …

Background: Available in-vitro and animal studies indicate that inflammation impacts
cytochromes P450 (CYP) activity via multiple and complex transcriptional and post …

Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been
declared a global pandemic and urgent treatment and prevention strategies are needed …

Objectives Favipiravir has discrepant activity against SARS-CoV-2 in vitro, concerns about
teratogenicity and pill burden, and an unknown optimal dose. This analysis used available …

Repurposing approved drugs may rapidly establish effective interventions during a public
health crisis. This has yielded immunomodulatory treatments for severe coronavirus disease …

Background The nitazoxanide plus atazanavir/ritonavir for COVID-19 (NACOVID) trial
investigated the efficacy and safety of repurposed nitazoxanide combined with …

In the absence of drugs to treat or prevent COVID-19, drug repurposing can be a valuable
strategy. Despite a substantial number of clinical trials, drug repurposing did not deliver on …

Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the
treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal …

The therapeutic potential of antigen-specific regulatory T cells (Treg) has been extensively
explored, leading to the development of several tolerogenic vaccines. Dexamethasone …