Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical
evidence has linked cell metabolism with cancer outcomes. Together, these observations …

Pluronic® block copolymers have been used extensively in a variety of pharmaceutical
formulations including delivery of low molecular mass drugs and polypeptides. This review …

Accelerated glucose metabolism is a common feature of cancer cells. Hexokinases catalyze
the first committed step of glucose metabolism. Hexokinase 2 (HK2) is expressed at high …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Slow-growing cell populations located within solid tumors are difficult to target selectively
because most cells in normal tissues also have low replication rates. However, a …

While chemotherapy remains the most effective treatment for disseminated tumors, acquired
or intrinsic drug resistance accounts for approximately 90% of treatment failure. Multidrug …

Pluronicв block copolymers are recognized pharmaceutical excipients listed in the US and
British Pharmacopoeia. The incorporation of drugs into Pluronic micelles results in …

Nutrient deprivation has been shown to cause cancer cell death. To exploit nutrient
deprivation as anti-cancer therapy, we investigated the effects of the anti-metabolite 2-deoxy …

When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the
ATP-dependent efflux pump P-glycoprotein (MDR1, P-gp, ABCB1). P-gp can efflux a wide …

The lactate dehydrogenase A (LDH-A) gene, whose product participates in normal
anaerobic glycolysis and is frequently increased in human cancers, has been identified as a …