Streptomycetes are high G+ C Gram-positive, antibiotic-producing, soil bacteria that undergo
complex morphological differentiation (Chater, 2001). The 8.7 Mb Streptomyces coelicolor …

Covering: 1990 to 2019 Many medicinally-relevant compounds are derived from non-
ribosomal peptide synthetase (NRPS) products. Type I NRPSs are organized into large …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Thiocoraline is a thiodepsipeptide antitumor compound produced by two actinomycetes
Micromonospora sp. ACM2‐092 and Micromonospora sp. ML1, isolated from two marine …

Microbial life in soil is fueled by dissolved organic matter (DOM) that leaches from the litter
layer. It is well known that decomposer communities adapt to the available litter source, but it …

1. Introduction.±Many of the natural fatty acid glycosides are biologically active chemical
complexes that include the molecules of fatty (carboxylic) and dicarboxylic (dioic) acids, fatty …

ABSTRACT A method was developed for the heterologous expression of biosynthetic gene
clusters in different Streptomyces strains and for the modification of these clusters by single …

In the biosynthetic gene cluster of the aminocoumarin antibiotic clorobiocin, the small ORF
cloY encodes a 71 aa protein which shows significant sequence similarity to mbtH from the …

The natural product specialized metabolites produced by microbes and plants are the
backbone of our current drugs. Ironically, we are in a golden age of understanding natural …

Many microorganisms produce secondary metabolites that have antibiotic activity. To avoid
self-inhibition, the producing cells often encode cognate export and/or resistance …