Haematopoietic stem cell activity and interactions with the niche
S Pinho, PS Frenette - Nature reviews Molecular cell biology, 2019 - nature.com
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
[HTML][HTML] The role of the CXCL12/CXCR4/CXCR7 chemokine axis in cancer
Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …
Leukaemia: a model metastatic disease
AE Whiteley, TT Price, G Cantelli, DA Sipkins - Nature Reviews Cancer, 2021 - nature.com
In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …
Tumor microenvironment and therapeutic response
T Wu, Y Dai - Cancer letters, 2017 - Elsevier
The tumor microenvironment significantly influences therapeutic response and clinical
outcome. Microenvironment-mediated drug resistance can be induced by soluble factors …
outcome. Microenvironment-mediated drug resistance can be induced by soluble factors …
Utilizing chemokines in cancer immunotherapy
Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have
demonstrated stunning clinical efficacy in many cancer types. However, most patients do not …
demonstrated stunning clinical efficacy in many cancer types. However, most patients do not …
Tumor microenvironment: Sanctuary of the devil
L Hui, Y Chen - Cancer letters, 2015 - Elsevier
Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence
indicates that targeting the tumor microenvironment could complement traditional treatment …
indicates that targeting the tumor microenvironment could complement traditional treatment …
Microenvironmental regulation of therapeutic response in cancer
The tumor microenvironment (TME) not only plays a pivotal role during cancer progression
and metastasis but also has profound effects on therapeutic efficacy. In the case of …
and metastasis but also has profound effects on therapeutic efficacy. In the case of …
Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia
Abstract B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell
death at the mitochondrion. It remains a challenge to identify those tumors that are best …
death at the mitochondrion. It remains a challenge to identify those tumors that are best …
The intricate role of CXCR4 in cancer
S Chatterjee, BB Azad, S Nimmagadda - Advances in cancer research, 2014 - Elsevier
Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …
CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks
Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …