An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Diseases that induce a loss of renal function affect a substantial portion of the world's
population and can range from a slight decline in the glomerular filtration rate or …

A key role for podocytes in the pathogenesis of proteinuric renal diseases has been
established. Angiotensin II causes depolarization and increased intracellular calcium …

Podocyte number is significantly reduced in diabetic patients and animal models, but the
mechanism remains unclear. In the present study, we found that high glucose induced …

Proteinuria is an independent risk factor for end‐stage renal disease (ESRD)(Shankland,
2006). Recent studies highlighted the mechanisms of podocyte injury and implications for …

Canonical transient receptor potential-6 (TRPC6) channels have been implicated in the
pathophysiology of glomerular diseases. TRPC6 channels are typically activated by …

Introduction: NMDA receptor (NMDAR) is an ionotropic glutamate receptor with a high
permeability to calcium and a unique feature of controlling numerous calcium-dependent …

The cGMP-dependent protein kinase-1α (PKG1α) transduces NO and natriuretic peptide
signaling; therefore, PKG1α activation can benefit the failing heart. Disease modifiers such …

Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases.
Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII …

Background Cigarette smoking plays an important role in the progression of chronic kidney
disease (CKD). Nicotine, one of the major components of cigarette smoking, has been …