Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

Epigenetic information in the mammalian oocyte has the potential to be transmitted to the
next generation and influence gene expression; this occurs naturally in the case of imprinted …

The oocyte-to-embryo transition (OET) arguably initiates with formation of a primordial
follicle and culminates with reprogramming of gene expression during the course of zygotic …

The shift from maternal to embryonic control is a critical developmental milestone in
preimplantation development. Widespread transcriptomic and epigenetic remodeling …

Oocyte maturation is pertinent to the success of in vitro maturation (IVM), which is used to
overcome female infertility, and produced over 5000 live births worldwide. However, the …

Meiotic maturation is an intricate and precisely regulated process orchestrated by various
pathways and numerous proteins. However, little is known about the proteome landscape …

Background Studies have shown that sperm-borne microRNAs (miRNAs) are involved in
mammalian preimplantation embryonic development. In humans, spermatozoan miR-34c …

Understanding factors that regulate zygotic genome activation (ZGA) is critical for
determining how cells are reprogrammed to become totipotent or pluripotent. There is …

Mammalian embryogenesis depends on maternal factors accumulated in eggs prior to
fertilization and on placental transfers later in gestation. In this review, we focus on initial …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development. However, the subtle changes in DNA methylation differ in species, and, little …