Nanotechnological approaches in prostate cancer therapy: integration of engineering and biology

M Ashrafizadeh, S Aghamiri, SC Tan, A Zarrabi… - Nano Today, 2022 - Elsevier
Nanocarriers have received special attention in biomedicine for the treatment of various
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Z Meng, H Xue, T Wang, B Chen, X Dong… - Journal of …, 2022 - Springer
Cancer remains a serious threat to human health owing to the lack of effective treatments.
Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment …

Gene expression based inference of cancer drug sensitivity

S Chawla, A Rockstroh, M Lehman, E Ratther… - Nature …, 2022 - nature.com
Inter and intra-tumoral heterogeneity are major stumbling blocks in the treatment of cancer
and are responsible for imparting differential drug responses in cancer patients. Recently …

Recent advances in the management of metastatic prostate cancer

N Sayegh, U Swami, N Agarwal - JCO Oncology Practice, 2022 - ascopubs.org
Management of metastatic prostate cancer has undergone a revolution over the past decade
with the introduction of several novel agents and repurposing of others. Several clinical trials …

Targeting tumor and bone microenvironment: Novel therapeutic opportunities for castration-resistant prostate cancer patients with bone metastasis

S Li, Y Kang, Y Zeng - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Despite standard hormonal therapy that targets the androgen receptor (AR) attenuates
prostate cancer (PCa) effectively in the initial stage, the tumor ultimately converts to …

Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer

J Kang, F La Manna, F Bonollo, N Sampson, IL Alberts… - Cancer letters, 2022 - Elsevier
During disease progression from primary towards metastatic prostate cancer (PCa), and in
particular bone metastases, the tumor microenvironment (TME) evolves in parallel with the …

Immune checkpoint inhibitors in prostate cancer

S Venkatachalam, TR McFarland, N Agarwal, U Swami - Cancers, 2021 - mdpi.com
Simple Summary Metastatic prostate cancer is an incurable disease with limited treatment
options. Immunotherapy has demonstrated significant success in multiple cancer types but …

Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer

NM Fonseca, C Maurice-Dror, C Herberts, W Tu… - Nature …, 2024 - nature.com
No consensus strategies exist for prognosticating metastatic castration-resistant prostate
cancer (mCRPC). Circulating tumor DNA fraction (ctDNA%) is increasingly reported by …

Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity

TC Westbrook, X Guan, E Rodansky, D Flores… - Nature …, 2022 - nature.com
The androgen receptor (AR) signaling inhibitor enzalutamide (enza) is one of the principal
treatments for metastatic castration-resistant prostate cancer (CRPC). Several emergent …

Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment

Y Guan, W Zhang, Y Mao, S Li - Molecular Cancer, 2024 - Springer
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate
from bone tissues and can be classified into primary and secondary types. Due to the …