Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

Objectives This study examines the relationship between synovial hypoxia and cellular
bioenergetics with synovial inflammation. Methods Primary rheumatoid arthritis synovial …

A consistent feature of neurons in patients with mental retardation is abnormal dendritic
structure and/or alterations in dendritic spine morphology. Deficits in the regulation of the …

Of 11 genes involved in nonspecific X-linked mental retardation (MRX), three encode
regulators or effectors of the Rho GTPases, suggesting an important role for Rho signaling in …

Drosophila Scribble is implicated in the development of normal synapse structure and
epithelial tissues, but it remains unclear how it plays a role and which process it controls [1 …

The GIT proteins, GIT1 and GIT2, are GTPase-activating proteins (inactivators) for the ADP-
ribosylation factor (Arf) small GTP-binding proteins, and function to limit the activity of Arf …

Rho GTPases are molecular switches involved in the regulation of many cellular processes.
This review summarizes work examining how stimulation of receptor tyrosine kinases …

The Rho family GTPase Cdc42 regulates cytoskeletal organization and membrane
trafficking in physiological processes such as cell proliferation, motility and polarity. Aberrant …

FAK, a cytoplasmic protein tyrosine kinase, is activated and localized to focal adhesions
upon cell attachment to extracellular matrix. FAK null cells spread poorly and exhibit altered …