Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its
activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of
the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in …

Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …

Beige and brown adipocytes generate heat in response to reductions in ambient
temperature. When warmed, both beige and brown adipocytes exhibit morphological" …

Public health studies indicate that artificial light is a high-risk factor for metabolic disorders.
However, the neural mechanism underlying metabolic modulation by light remains elusive …

Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction
of browning in white adipose tissue. Although FGF21 stimulated browning results from a …

The enormous plasticity of adipose tissues, to rapidly adapt to altered physiological states of
energy demand, is under neuronal and endocrine control. In energy balance, lipolysis of …

Homeostatic regulation of adipose tissue is critical for the maintenance of energy balance
and whole-body metabolism. The peripheral nervous system provides bidirectional neural …