Metastatic melanoma is challenging to manage. Although targeted-and immune therapies
have extended survival, most patients experience therapy resistance. The adaptability of …

Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Cell-in-cell structures are reported in numerous cancers, and their presence is an indicator
for poor prognosis. Mechanistic studies have identified how cancer cells manage to ingest …

Background: Resistance to antitumor agents is a major cause of treatment failure in patients
with cancer. Some mechanisms of tumor resistance to cytotoxic drugs may involve increased …

One of the characteristics of cancer cells important for tumorigenesis is their metabolic
plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic …

The causes of metastasis remain elusive despite vast information on cancer cells. We posit
that cancer cell fusion with macrophages or other migratory bone marrow-derived cells …

The phenomenon of cell cannibalism, which generally refers to the engulfment of cells within
other cells, was described in malignant tumors, but its biological significance is still largely …

Tumor microenvironment may play a key role in tumor malignancy. It is hypothesized that
hypoxia and acidity may contribute to the progression from benign to malignant growth. In …

Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having
immuno-modulating properties. This bacterium is an example of a microorganism inducing …