Vaccination is generally considered to be the most effective method of preventing infectious
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …

A large volume of data relevant to immunology research has accumulated due to
sequencing of genomes of the human and other model organisms. At the same time, huge …

The accurate prediction of the binding affinities of ligands to proteins is a major goal in drug
discovery and personalized medicine. The time taken to make such predictions is of similar …

Molecular dynamics simulations have to be sufficiently long to draw reliable conclusions.
However, no method exists to prove that a simulation has converged. We suggest the …

We discuss the modern approaches of complexity and self-organization to understanding
dynamical systems and how these concepts can inform current interest in systems biology …

Recognition by the T‐cell receptor (TCR) of immunogenic peptides (p) presented by class I
major histocompatibility complexes (MHC) is the key event in the immune response against …

Background MHC class II proteins bind oligopeptide fragments derived from proteolysis of
pathogen antigens, presenting them at the cell surface for recognition by CD4+ T cells …

Xenorhabdus nematophila secretes insecticidal proteins to kill its larval prey. We have
isolated an∼ 58-kDa GroEL homolog, secreted in the culture medium through outer …

An interesting property of certain peptides presented by major histocompatibility complex
(MHC) molecules is their acquisition of a dual binding mode within the peptide binding …

A reflection of the explosion of research and development in this field, this book explores
applications of omics in bioinformatics, cancer research and therapy, diabetes research …