Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal
loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Herein we review our recent efforts in searching for bioactive ligands by enumeration and
virtual screening of the unknown chemical space of small molecules. Enumeration from first …

Muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs) are
emerging as important targets for the development of novel treatments for the symptoms …

EVP-6124,(R)-7-chloro-N-quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide, is a novel
partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) that was evaluated …

A promising drug target currently under investigation to improve cognitive deficits in
neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine …

The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Agonists and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
(nAChR) are currently being developed for the treatment of cognitive disturbances in …

The decades‐old cholinergic hypothesis of Alzheimer's disease (AD) led to clinical testing
and FDA approval of acetylcholinesterase inhibitor drugs. Subsequently, the α7 nicotinic …