Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic
target. Here we report the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 …

Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …

Autophagy classically functions as a physiological process to degrade cytoplasmic
components, protein aggregates, and/or organelles, as a mechanism for nutrient …

MYOD-directed fibroblast trans-differentiation into skeletal muscle provides a unique model
to investigate how one transcription factor (TF) reconfigures the three-dimensional chromatin …

The Signal Transducer and Activator of Transcription (STAT) 3 and 5 proteins are activated
by many cytokine receptors to regulate specific gene expression and mitochondrial …

Imbalances in redox homeostasis can result in oxidative stress, which is implicated in
various pathological conditions including the fatal neuromuscular disease Duchenne …

Peripheral nerve injury is common, and can lead to skeletal muscle atrophy and dysfunction.
However, the underlying molecular mechanisms are not fully understood. The transcription …