[HTML][HTML] The neurobiology of long COVID

M Monje, A Iwasaki - Neuron, 2022 - cell.com
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of
people after COVID-19 and represent a major component of the post-acute COVID-19 …

Microglia: Immune and non-immune functions

K Borst, AA Dumas, M Prinz - Immunity, 2021 - cell.com
As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …

[HTML][HTML] Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

A Fernández-Castañeda, P Lu, AC Geraghty, E Song… - Cell, 2022 - cell.com
COVID survivors frequently experience lingering neurological symptoms that resemble
cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial …

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

S De Schepper, JZ Ge, G Crowley, LSS Ferreira… - Nature …, 2023 - nature.com
Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …

A guide to complement biology, pathology and therapeutic opportunity

DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

[HTML][HTML] Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease

DK Wilton, K Mastro, MD Heller, FW Gergits… - Nature medicine, 2023 - nature.com
Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

How COVID-19 affects the brain

M Boldrini, PD Canoll, RS Klein - JAMA psychiatry, 2021 - jamanetwork.com
COVID-19 has resulted in more than 120 million cases and 2.6 million deaths to date.
Respiratory and gastrointestinal symptoms are accompanied by short-and long-term …

COVID-19 neuropathology at columbia university irving medical center/New York presbyterian hospital

KT Thakur, EH Miller, MD Glendinning, O Al-Dalahmah… - Brain, 2021 - academic.oup.com
Many patients with SARS-CoV-2 infection develop neurological signs and symptoms;
although, to date, little evidence exists that primary infection of the brain is a significant …

Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients

Y Yachou, A El Idrissi, V Belapasov, S Ait Benali - Neurological Sciences, 2020 - Springer
Respiratory viruses are opportunistic pathogens that infect the upper respiratory tract in
humans and cause severe illnesses, especially in vulnerable populations. Some viruses …

Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system?

M Desforges, A Le Coupanec, P Dubeau, A Bourgouin… - viruses, 2019 - mdpi.com
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases.
However, in vulnerable populations, such as newborns, infants, the elderly and immune …