[HTML][HTML] Paracetamol use during pregnancy—a call for precautionary action

AZ Bauer, SH Swan, D Kriebel, Z Liew… - Nature Reviews …, 2021 - nature.com
Abstract Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as
acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to …

Anesthesia and developing brains: unanswered questions and proposed paths forward

C Ing, DO Warner, LS Sun, RP Flick, AJ Davidson… - …, 2022 - pubs.asahq.org
Anesthetic agents disrupt neurodevelopment in animal models, but evidence in humans is
mixed. The morphologic and behavioral changes observed across many species predicted …

[HTML][HTML] Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis …

S Alemany, C Avella-García, Z Liew… - European journal of …, 2021 - Springer
The potential etiological role of early acetaminophen exposure on Autism Spectrum
Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We …

[HTML][HTML] Paracetamol (acetaminophen) and the developing brain

C Bührer, S Endesfelder, T Scheuer… - International journal of …, 2021 - mdpi.com
Paracetamol is commonly used to treat fever and pain in pregnant women, but there are
growing concerns that this may cause attention deficit hyperactivity disorder and autism …

[HTML][HTML] The main changes in pregnancy—therapeutic approach to musculoskeletal pain

F Fiat, PE Merghes, AD Scurtu, B Almajan Guta… - Medicina, 2022 - mdpi.com
Background and Objectives: During pregnancy, women undergo various physiological and
anatomical changes that are accentuated as the pregnancy progresses, but return to their …

[HTML][HTML] Sex-specific neurobehavioral and prefrontal cortex gene expression alterations following developmental acetaminophen exposure in mice

BH Baker, EE Rafikian, PB Hamblin, MD Strait… - Neurobiology of …, 2023 - Elsevier
Abstract Acetaminophen (N-acetyl-p-aminophenol (APAP), also known as paracetamol) is
one of the most common medications used by the general population, including pregnant …

[HTML][HTML] Examining the relationship of acetaminophen use during pregnancy with early language development in children

ML Woodbury, P Cintora, S Ng, PA Hadley… - Pediatric …, 2024 - nature.com
Background Acetaminophen is the only analgesic considered safe for use throughout
pregnancy. Recent studies suggest that use during pregnancy may be associated with …

[HTML][HTML] The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood

ML Woodbury, SD Geiger, SL Schantz - Neurotoxicology and teratology, 2024 - Elsevier
Acetaminophen is currently the only analgesic considered safe for use throughout
pregnancy, but recent studies indicate that prenatal exposure to acetaminophen may be …

[HTML][HTML] Analgesic drug use in pregnancy and neurodevelopment outcomes: an umbrella review

J Kwok, E Luedecke, HA Hall, AL Murray… - … & Biobehavioral Reviews, 2022 - Elsevier
Emerging evidence from reviews suggests that analgesic drug exposure during pregnancy
may contribute to child neurodevelopment outcomes. A comprehensive overview of existing …

Intrauterine exposure to acetaminophen and adverse developmental outcomes: epidemiological findings and methodological issues

Z Liew, A Ernst - Current Environmental Health Reports, 2021 - Springer
Abstract Purpose of Review Acetaminophen (or paracetamol) is one of the most commonly
used medications during pregnancy. We reviewed recent epidemiological evidence …