In the last several decades, there have been significant advances in anticancer therapy.
However, the development of resistance to cancer drugs and the lack of specificity related to …

In spite of great advances in cancer therapy, there is considerable current interest in
developing anticancer agents with a new mode of action because of the development of …

The mechanism of action of buforin II, which is a 21-amino acid peptide with a potent
antimicrobial activity against a broad range of microorganisms, was studied using …

Magainin, found in the skin of Xenopus laevis, belongs to a broad class of antimicrobial
peptides which kill bacteria by permeabilizing the cytoplasmic membrane but do not lyse …

With the steady rise in the number of antibiotic-resistant Gram-positive pathogens, it has
become increasingly important to find new antibacterial agents which are highly active and …

Cancer treatment by conventional chemotherapy is hindered by toxic side effects and the
frequent development of multi-drug resistance by cancer cells. Cationic antimicrobial …

Magainins are a class of antimicrobial peptides discovered in the skin of Xenopus laevis.
The peptides kill bacteria by permeabilizing the cell membranes without exhibiting …

The structure and functions of membrane-active peptides are extensively reviewed. These
peptides including cecropins from insects, melittin from honey bees (Apis mellifera) and …

Antimicrobial peptides isolated from vertebrates provide defense against pathogenic
microorganisms by using both nonspecific physical barriers and highly-specific responses of …

Cationic antimicrobial peptides (AMPs) and host defense peptides (HDPs) show vast
potential as peptide-based drugs. Great effort has been made in order to exploit their …