[HTML][HTML] Overview on peroxiredoxin

SG Rhee - Molecules and cells, 2016 - Elsevier
Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that
reduce peroxides, with a conserved cysteine residue, designated the “peroxidatic” Cys (CP) …

[HTML][HTML] Withania somnifera (L.) Dunal: opportunity for clinical repurposing in COVID-19 management

A Saggam, K Limgaokar, S Borse… - Frontiers in …, 2021 - frontiersin.org
As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional
management have highlighted the need for the integration of traditional knowledge systems …

Comparative estimation of sulfiredoxin levels between chronic periodontitis and healthy patients–A case‐control study

A Ramesh, S Varghese, ND Jayakumar… - Journal of …, 2018 - Wiley Online Library
Background Growing evidence suggests that oxidative stress forms a key component in the
etiopathogenesis of periodontitis. Studies have shown potential antioxidants responsible for …

Discovering mechanisms of signaling-mediated cysteine oxidation

LB Poole, KJ Nelson - Current opinion in chemical biology, 2008 - Elsevier
Accumulating evidence reveals hydrogen peroxide as a key player both as a damaging
agent and, from emerging evidence over the past decade, as a second messenger in …

Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases

MH Park, MR Jo, YR Kim, CK Lee, JT Hong - Pharmacology & Therapeutics, 2016 - Elsevier
Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to
balance cellular hydrogen peroxide (H 2 O 2) levels, which are essential for cell signaling …

Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin

B Knoops, J Goemaere, V Van der Eecken… - Antioxidants & redox …, 2011 - liebertpub.com
Abstract Peroxiredoxin 5 (PRDX5) was the last member to be identified among the six
mammalian peroxiredoxins. It is also the unique atypical 2-Cys peroxiredoxin in mammals …

[HTML][HTML] Multiple roles of peroxiredoxins in inflammation

B Knoops, V Argyropoulou, S Becker, L Ferté… - Molecules and cells, 2016 - Elsevier
Inflammation is a pathophysiological response to infection or tissue damage during which
high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill …

[HTML][HTML] Novel concepts in radiation-induced cardiovascular disease

JR Cuomo, GK Sharma, PD Conger… - World journal of …, 2016 - ncbi.nlm.nih.gov
Radiation-induced cardiovascular disease (RICVD) is the most common nonmalignant
cause of morbidity and mortality among cancer survivors who have undergone mediastinal …

Traumatic brain injury induces macrophage subsets in the brain

CL Hsieh, CC Kim, BE Ryba, EC Niemi… - European journal of …, 2013 - Wiley Online Library
Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary
brain injury. To better understand the mechanisms involved in TBI‐induced inflammation, we …

Peroxiredoxins as potential targets for cardiovascular disease

SJ Jeong, JG Park, GT Oh - Antioxidants, 2021 - mdpi.com
Increased oxidative stress (OS) is considered a common etiology in the pathogenesis of
cardiovascular disease (CVD). Therefore, the precise regulation of reactive oxygen species …