Pioneer transcription factors are proteins with a dual function. First, they regulate
transcription by binding to nucleosome-free DNA regulatory elements. Second, they bind to …

Chromatin plays a key role in regulating gene expression programs necessary for the
orderly progress of development and for preventing changes in cell identity that can lead to …

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications in
diabetes. Previous studies have shown that chronic neuroinflammation was associated with …

Chromatin organization is a highly orchestrated process that influences gene expression, in
part by modulating access of regulatory factors to DNA and nucleosomes. Here, we report …

White adipose tissue browning is a key metabolic process controlled by epigenetic factors
that facilitate changes in gene expression leading to altered cell identity. We find that male …

Direct neuronal reprogramming potentially provides valuable sources for cell-based
therapies. Proneural gene Ascl1 converts astrocytes into induced neuronal (iN) cells …

Recent technological advances have expanded the annotated protein coding content of
mammalian genomes, as hundreds of previously unidentified, short open reading frame …

Genome architecture and chromatin dynamics govern the fate and identify of a cell. Recent
advances in mapping chromatin landscapes offer valuable tools for the acquisition of …

Differentiation of stem and progenitor cells is a highly regulated process that involves the
coordinated action of multiple layers of regulation. Here we show how the post …

Nucleosomes containing acetylated H3K27 are a major epigenetic mark of active chromatin
and identify cell-type specific chromatin regulatory regions which serve as binding sites for …