Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Conventional dendritic cells (cDCs) are professional antigen-presenting cells that control the
adaptive immune response. Their subsets and developmental origins have been intensively …

Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective
anti-cancer immunity is thought to require cDC1s to sustain T cell responses within tumors …

Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs),
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver …

Tissue-resident macrophages (TRMs) and dendritic cells (DCs) are highly heterogeneous
and essential for immunity, tissue regeneration, and homeostasis maintenance. Here, we …