The human immune system is a complex network of coordinated components that are
crucial for health and disease. Animal models, commonly used to study immunomodulatory …

Respiratory syncytial virus is a leading cause of morbidity and mortality in children, due in
part to their distinct immune system, characterized by impaired induction of Th 1 immunity …

Clinical manifestations from primary COVID infection in children are generally less severe as
compared to adults, and severe pediatric cases occur predominantly in children with …

Adjuvants are vaccine components that can boost the type, magnitude, breadth, and
durability of an immune response. We have previously demonstrated that certain adjuvant …

We describe a methodology utilizing high-throughput and high-content screening for novel
adjuvant candidates that was used to screen a library of~ 2,500 small molecules via a 384 …

In humans, the interindividual variability of clinical outcome following exposure to a
microorganism is immense, ranging from silent infection to life-threatening disease. Age …

High-throughput screening is a powerful platform that can rapidly provide valuable cytotoxic,
immunological, and phenotypical information for thousands of compounds. Human …