Ossification is a tightly regulated process, performed by specialized cells called osteoblasts.
Dysregulation of this process may cause inadequate or excessive mineralization of bones or …

This authoritative survey discusses how tumor cells cause bone metastases by producing
both local and systemic factors that disrupt the balance between bone formation and bone …

Bone is a dynamic tissue that is constantly renewed. The cell populations that participate in
this process—the osteoblasts and osteoclasts—are derived from different progenitor pools …

A preliminary expression profiling analysis of osteoblasts derived from tibia explants of the
high bone mass LRP5 G171V transgenic mice demonstrated increased expression of …

Tumor necrosis factor-α (TNF) is one member of a large family of inflammatory cytokines that
share common signal pathways, including activation of the transcription factor nuclear factor …

Osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) are
regarded as being of great importance in the regulation of bone remodeling. In this study, rat …

Caspase-3 is a critical enzyme for apoptosis and cell survival. Here we report delayed
ossification and decreased bone mineral density in caspase-3–deficient (Casp3–/–and …

In the last two decades, numerous scientists have highlighted the interactions between bone
and immune cells as well as their overlapping regulatory mechanisms. For example …

Certain exercises can induce osteogenesis and improve bone strength, yet the biological
processes involved in bone mechanotransduction are only beginning to be understood …

Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis
and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and …