Alkaline phosphatase: an old friend as treatment target for cardiovascular and mineral bone disorders in chronic kidney disease

M Haarhaus, G Cianciolo, S Barbuto, G La Manna… - Nutrients, 2022 - mdpi.com
Alkaline phosphatase (ALP) is an evolutionary conserved enzyme and widely used
biomarker in clinical practice. Tissue-nonspecific alkaline phosphatase (TNALP) is one of …

A meta-omics approach to explore the biofuel-producing enzyme potential from extreme environmental conditions

S Dixit, K Sahoo, M Gaur, RK Sahoo, S Dey… - … and Sustainable Energy …, 2023 - Elsevier
Geothermally warmed spring water contaminated with decomposed leaf biomass are unique
hot spring ecosystems, are expected to support the recycling of various nutrients and to host …

Intranuclear nanoribbons for selective killing of osteosarcoma cells

S Liu, Q Zhang, H He, M Yi, W Tan… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …

Explainable machine learning framework to predict personalized physiological aging

D Bernard, E Doumard, I Ader, P Kemoun, J Pagès… - Aging cell, 2023 - Wiley Online Library
Attaining personalized healthy aging requires accurate monitoring of physiological changes
and identifying subclinical markers that predict accelerated or delayed aging. Classic …

Diagnostic approach to patients with low serum alkaline phosphatase

JA Riancho - Calcified tissue international, 2023 - Springer
Increased serum levels of alkaline phosphatase (ALP) are widely recognized as a
biochemical marker of many disorders affecting the liver or bone. However, the approach for …

Self‐Activating Phosphorus‐Rich Substrate Import Enzyme Catalytic Domains for Bone Regeneration

Q Zhao, J Chen, J Tang, X Lei, J Zhang… - Advanced Functional …, 2024 - Wiley Online Library
Enzymes play a key role in natural mineralization, but their function is disabling in bone
metabolism when patients suffer severe degenerations like hypophosphatasia. To regulate …

Stanniocalcin 1 and 1,25-dihydroxyvitamin D3 cooperatively regulate bone mineralization by osteoblasts

JH Kim, K Kim, I Kim, S Seong, JT Koh… - Experimental & Molecular …, 2024 - nature.com
Abstract Stanniocalcin 1 (STC1) is a calcium-and phosphate-regulating hormone that is
expressed in all tissues, including bone tissues, and is involved in calcium and phosphate …

Hydroxyapatite/poly (vinyl alcohol)/chitosan coating with gentamicin for orthopedic implants

M Djošić, A Janković, M Stevanović, J Stojanović… - Materials Chemistry and …, 2023 - Elsevier
Electrophoretic deposition (EPD) was employed to fabricate composite coatings aimed for
orthopedic implants. Hydroxyapatite (HAP), poly (vinyl alcohol)(PVA) and chitosan (CS) …

Diet supplementation of organic zinc positively affects growth, antioxidant capacity, immune response and lipid metabolism in juvenile largemouth bass, Micropterus …

X He, A Chen, Z Liao, Y Zhang, G Lin… - British Journal of …, 2023 - cambridge.org
Zn is an important trace element involved in various biochemical processes in aquatic
species. An 8-week rearing trial was thus conducted to investigate the effects of Zn on …

Nanocomposites containing ZnO-TiO2-Chitosan and berbamine promote osteoblast differentiation, proliferation, and calcium mineralization in MG63 osteoblasts

S Guo, Z Zhang, L Cao, T Wu, B Li, Y Cui - Process Biochemistry, 2023 - Elsevier
Recently, biomedical research has focused on bio-nanocomposites that are capable of
regeneration of tissues, as well as treating osteomyelitis, osteosarcoma, and other diseases …