Cancer cachexia (CC) is a complicated metabolic derangement and muscle wasting
syndrome, affecting 50–80% cancer patients. So far, molecular mechanisms underlying CC …

Post-translational modifications (PTMs) can occur soon after translation or at any stage in
the lifecycle of a given protein, and they may help regulate protein folding, stability, cellular …

Liquid chromatography coupled with bottom-up mass spectrometry (LC-MS/MS)–based
proteomics is increasingly used to detect changes in posttranslational modifications (PTMs) …

In the era of open-modification search engines, more post-translational modifications than
ever can be detected by LC-MS/MS-based proteomics. This development can switch …

Protein modifications modulate nearly every aspect of cell biology in organisms, ranging
from Archaea to Eukaryotes. The earliest evidence of covalent protein modifications was …

Diatoms comprise a diverse and ecologically important group of eukaryotic phytoplankton
that significantly contributes to marine primary production and global carbon cycling …

Mass spectrometry is being used to identify protein biomarkers that can facilitate
development of drug treatment. Mass spectrometry-based labeling proteomic experiments …

Abstract Trastuzumab-MCC-DM1 (T-DM1) is an antibody-drug conjugate (ADC) that consists
of a monoclonal antibody (mAb) trastuzumab non-cleavably linked to a cytotoxic drug DM1 …

Plant cell wall proteins (CWPs) and peptides are important players in cell walls contributing
to their assembly and their remodeling during development and in response to …

Protein phosphorylation is one of the most important mechanisms regulating metabolism as
it can directly modify metabolic enzymes by the addition of phosphate groups. Attributed to …