The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …

The tumor suppressor p53 functions predominantly as a transcription factor by activating and
downregulating gene expression, leading to cell cycle arrest or apoptosis. p53 was shown to …

Epithelial-to-mesenchymal transition (EMT) is strongly associated with cancer progression,
but its potential role during premalignant development has not been studied. Here, we show …

Mammalian euchromatic gene silencing results from the combined repressive effects of
histone and DNA methyltransferases. Little is known of the mechanism by which these …

Histone Arg methylation has been correlated with transcriptional activation of p53 target
genes. However, whether this modification is reversed to repress the expression of p53 …

The predominant function of the tumor suppressor p53 is transcriptional regulation. It is
generally accepted that p53-dependent transcriptional activation occurs by binding to a …

Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone, PLB), a naturally occurring
naphthoquinone mainly isolated from the plant Plumbago zeylanica L., has been proven to …

Abstract UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multi-
domain protein associated with cellular proliferation and epigenetic regulation. The UHRF1 …

The p53 tumor suppressor protein is a transcription factor that exerts its effects on the cell
cycle via regulation of gene expression. Although the mechanism of p53-dependent …