Cryo-electron microscopy (cryo-EM) is rapidly becoming an attractive method in the field of
structural biology. With the exploding popularity of cryo-EM, sample preparation must evolve …

Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is
an interdisciplinary field that takes advantage of advances in biochemistry, physics, and …

NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular
signalling complexes known as canonical inflammasomes, resulting in caspase− 1 …

We review the growing use of machine learning in electron microscopy (EM) driven in part
by the availability of fast detectors operating at kiloHertz frame rates leading to large data …

Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for
visualizing biological objects, which has been driven by advances across the entire pipeline …

Single particle cryo-EM requires full automation to allow high-throughput structure
determination. Although software packages exist where parts of the cryo-EM pipeline are …

Cryo-electron microscopy (cryo-EM) has become an unrivaled tool for determining the
structure of macromolecular complexes. The biological function of macromolecular …

Amyloids share a common architecture but play disparate biological roles in processes
ranging from bacterial defense mechanisms to protein misfolding diseases. Their structures …

Cryo-sample preparation is a vital step in the process of obtaining high-resolution structures
of macromolecules by using the single-particle cryo–electron microscopy (cryo-EM) method; …

Recent technical advances have dramatically increased the power and scope of structural
biology. New developments in high-resolution cryo-electron microscopy, serial X-ray …