Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …

Recent studies reported that pancreatic β-cells are heterogeneous in terms of their
transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic …

NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β
cells. Disruption of Neurod1 during pancreatic development causes severe neonatal …

Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Pancreatic β cells display functional and transcriptional heterogeneity in health and disease.
The sequence of events leading to β cell heterogeneity during metabolic stress is poorly …

Pancreatic β-cell failure due to a reduction in function and mass has been defined as a
primary contributor to the progression of type 2 diabetes (T2D). Reserving insulin-producing …

Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …

Pancreatic β-cell failure by WFS1 deficiency is manifested in individuals with wolfram
syndrome (WS). The lack of a suitable human model in WS has impeded progress in the …

Type 1 diabetes (T1D) presents a persistent medical challenge, demanding innovative
strategies for sustained glycemic control and enhanced patient well-being. Beta cells are …

De novo variants affecting monoubiquitylation of histone H2B (H2Bub1) are enriched in
human congenital heart disease. H2Bub1 is required in stem cell differentiation, cilia …