The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …

Lovastatin, a secondary metabolite isolated from fungi, is often used as a representative
drug to reduce blood lipid concentration and treat hypercholesterolemia. Its structure is …

Alzheimer's disease (AD) is the principal cause of dementia in older people, and
accumulation of amyloid-beta (Aβ) peptide is a crucial event in AD pathogenesis. Despite …

We are pleased to dedicate this paper to Dr Julian E Davies. Julian is a giant among
microbial biochemists. He began his professional career as an organic chemistry PhD …

Statins have recently been shown to act as protectants against several neuropathological
conditions. They have received special attention in the field of Alzheimer's disease (AD) …

In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the
parenchyma and cerebrovasculature. Several evidences support that the neuronal demise …

Alzheimer's disease (AD) is a multifactorial and multifaceted disease for which we currently
have very little to offer since there is no curative therapy, with only limited disease-modifying …

Fungi are amazing producers of natural products, including secondary metabolites. These
compounds are crucial to the health and well-being of people throughout the world. They …

Lovastatin, a secondary metabolite isolated from Monascus-fermented red rice mold, has
neuroprotective activity and permeates the blood–brain barrier. The aim of this study was to …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Although the main cause of the onset and development of AD is not known yet, neuronal …