Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

Cerebrovascular disease is the second most common cause of acquired cognitive
impairment and dementia and contributes to cognitive decline in the neurodegenerative …

Background Chronic hypertension, particularly midlife high blood pressure, has been
associated with an increased risk for cognitive decline and dementia. In this context …

The treatment of various central nervous system (CNS) diseases has been challenging,
despite the rapid development of several novel treatment approaches. The blood–brain …

The aim of this international guideline on dementia was to present a peer‐reviewed
evidence‐based statement for the guidance of practice for clinical neurologists, geriatricians …

The British Association for Psychopharmacology coordinated a meeting of experts to review
and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs. As …

Drug repurposing is a strategy consisting of finding new indications for already known
marketed drugs used in various clinical settings or highly characterized compounds despite …

Significance: Alzheimer's disease (AD) is the most common cause of dementia in the elderly.
AD is currently ranked as the sixth leading cause of death, but some sources put it as third …

Existing drugs for Alzheimer's disease provide symptomatic benefit for up to 12 months, but
there are no approved disease-modifying therapies. Given the recent failures of various …

Objective To summarise existing systematic reviews that assess the effects of non-
pharmacological, pharmacological and alternative therapies on activities of daily living …