Endometrial cancer
F Amant, P Moerman, P Neven, D Timmerman… - The Lancet, 2005 - thelancet.com
Each year, endometrial cancer develops in about 142 000 women worldwide, and an
estimated 42 000 women die from this cancer. The typical age-incidence curve for …
estimated 42 000 women die from this cancer. The typical age-incidence curve for …
PTEN: One Gene, Many Syndromes
C Eng - Human mutation, 2003 - Wiley Online Library
Abstract PTEN, on 10q23. 3, encodes a major lipid phosphatase which signals down the
phosphoinositol‐3‐kinase/Akt pathway and effects G1 cell cycle arrest and apoptosis …
phosphoinositol‐3‐kinase/Akt pathway and effects G1 cell cycle arrest and apoptosis …
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
M Tamura, J Gu, K Matsumoto, S Aota, R Parsons… - Science, 1998 - science.org
The tumor suppressor PTEN is a phosphatase with sequence similarity to the cytoskeletal
protein tensin. Here the cellular roles of PTEN were investigated. Overexpression of PTEN …
protein tensin. Here the cellular roles of PTEN were investigated. Overexpression of PTEN …
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
K Podsypanina, LH Ellenson… - Proceedings of the …, 1999 - National Acad Sciences
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the
endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type …
endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type …
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors
PTEN (phosphatase and tensin homolog) loss of function is the most common genetic
aberration in endometrioid endometrial carcinomas. In addition to its well-described role in …
aberration in endometrioid endometrial carcinomas. In addition to its well-described role in …
Molecular and pathologic aspects of endometrial carcinogenesis
JL Hecht, GL Mutter - Journal of clinical oncology, 2006 - ascopubs.org
Endometrial cancer is the most common gynecological malignancy, with 41,000 new cases
projected in the United States for 2006. Two different clinicopathologic subtypes are …
projected in the United States for 2006. Two different clinicopathologic subtypes are …
Nuclear transport and cancer: from mechanism to intervention
TR Kau, JC Way, PA Silver - Nature Reviews Cancer, 2004 - nature.com
Nuclear-cytoplasmic transport, which occurs through special structures called nuclear pores,
is an important aspect of normal cell function, and defects in this process have been …
is an important aspect of normal cell function, and defects in this process have been …
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
S Ramaswamy, N Nakamura… - Proceedings of the …, 1999 - National Acad Sciences
PTEN/MMAC1 is a tumor suppressor gene located on chromosome 10q23. Inherited
PTEN/MMAC1 mutations are associated with a cancer predisposition syndrome known as …
PTEN/MMAC1 mutations are associated with a cancer predisposition syndrome known as …
PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?
Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …
Definition of microRNAs That Repress Expression of the Tumor Suppressor Gene FOXO1 in Endometrial Cancer
SS Myatt, J Wang, LJ Monteiro, M Christian, KK Ho… - Cancer research, 2010 - AACR
Endometrial cancer is the most common malignancy of the lower female reproductive tract.
The tumor suppressor FOXO1 is downregulated in endometrial cancer compared with …
The tumor suppressor FOXO1 is downregulated in endometrial cancer compared with …