Stroke is a leading cause of long-term disability, and outcome is directly related to timely
intervention. Not all patients benefit from rapid intervention, however. Thus a significant …

Over the last 15 years, basic thresholding techniques in combination with standard statistical
correlation-based data analysis tools have been widely used to investigate different aspects …

The intraluminal filament model of middle cerebral artery occlusion (MCAO) in mice and rats
has been plagued by inconsistency, owing in part to the multitude of variables requiring …

The ischemic tissue becomes acidic after initiation of anaerobic respiration, which may result
in impaired tissue metabolism and, ultimately, in severe tissue damage. Although changes …

Amide proton transfer (APT) MRI is sensitive to ischemic tissue acidosis and has been
increasingly used as a research tool to investigate disrupted tissue metabolism during acute …

In acute ischemic stroke treatment, prediction of tissue survival outcome plays a fundamental
role in the clinical decision-making process, as it can be used to assess the balance of risk …

The human brain is possibly the most complex organ in existence. This complexity means
that it is capable of great feats, yet has ensured that it remains surprisingly poorly …

Stroke is the fourth leading cause of death and the leading cause of long-term disability in
the United States. Blood flow deficit results in an expanding infarct core with a time-sensitive …

In hemispheric ischemic stroke, the final size of the ischemic lesion is the most important
correlate of clinical functional outcome. Using a set of acute-phase MR images (Diffusion …

Early and accurate prediction of tissue outcome is essential to the clinical decision-making
process in acute ischemic stroke. We present a quantitative predictive model of tissue fate …