Role of C-reactive protein at sites of inflammation and infection

NR Sproston, JJ Ashworth - Frontiers in immunology, 2018 - frontiersin.org
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

[HTML][HTML] The endothelium and its role in regulating vascular tone

A Sandoo, JJCSV van Zanten, GS Metsios… - The open …, 2010 - ncbi.nlm.nih.gov
The endothelium forms an important part of the vasculature and is involved in promoting an
atheroprotective environment via the complementary actions of endothelial cell-derived …

High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

I Lozano, R Van der Werf, W Bietiger, E Seyfritz… - Nutrition & …, 2016 - Springer
Background As a result of the increased consumption of sugar-rich and fatty-products, and
the increase in preference for such products, metabolic disorders are becoming more …

Inflammation-associated co-morbidity between depression and cardiovascular disease

A Halaris - Inflammation-associated depression: Evidence …, 2017 - Springer
Morbidity and mortality of cardiovascular disease (CVD) is exceedingly high worldwide.
Depressive illness is a serious psychiatric illness that afflicts a significant portion of the world …

Is obesity an inflammatory condition?

UN Das - Nutrition, 2001 - Elsevier
Obesity may be a low-grade systemic inflammatory disease. Overweight and obese children
and adults have elevated serum levels of C-reactive protein, interleukin-6, tumor necrosis …

Novel clinical markers of vascular wall inflammation

GJ Blake, PM Ridker - Circulation research, 2001 - Am Heart Assoc
Inflammatory processes play a pivotal role in the pathogenesis of atherosclerosis and
mediate many of the stages of atheroma development from initial leukocyte recruitment to …

Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways

JE Ramsay, WR Ferrell, L Crawford… - The Journal of …, 2002 - academic.oup.com
Obesity is increasing in prevalence worldwide and in all age groups. In nonpregnant
individuals, obesity is associated with dyslipidemia; hyperinsulinemia; vascular dysfunction; …

Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells

SK Venugopal, S Devaraj, I Yuhanna, P Shaul, I Jialal - Circulation, 2002 - Am Heart Assoc
Background—C-reactive protein (CRP), the prototypic marker of inflammation, has been
shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide …

Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease

P Grammas - Journal of neuroinflammation, 2011 - Springer
Alzheimer's disease (AD) is an age-related disorder characterized by progressive cognitive
decline and dementia. Alzheimer's disease is an increasingly prevalent disease with 5.3 …

C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study

DJ Freeman, J Norrie, MJ Caslake, A Gaw, I Ford… - Diabetes, 2002 - Am Diabetes Assoc
Accumulating evidence implicates inflammation as a potential pathway in the pathogenesis
of type 2 diabetes. The objective of the present study was to assess the ability of C-reactive …