Congenital hyperinsulinism (HI) is an inappropriate insulin secretion by the pancreatic β-
cells secondary to various genetic disorders. The incidence is estimated at 1/50, 000 live …

The beta‐cell ATP‐sensitive potassium (KATP) channel is a key component of stimulus‐
secretion coupling in the pancreatic beta‐cell. The channel couples metabolism to …

Abstract Purpose & Methods Neuroendocrine neoplasms are a heterogenous group of
tumours, for which nuclear medicine plays an important role in the diagnostic work-up as …

Abstract Background Congenital Hyperinsulinism (HI) causes severe hypoglycemia in
neonates and children. We reviewed our experience with pancreatectomy for the various …

Hyperinsulinism is the single most common mechanism of hypoglycemia in neonates.
Dysregulated insulin secretion is responsible for the transient and prolonged forms of …

Pancreatic neoplasms are rare in children and have a different histologic spectrum and
prognosis than those in adults. In general, these tumors are well demarcated with expansile …

In recent years, 6-l-18F-fluorodihydroxyphenylalanine (18F-DOPA) PET has emerged as a
new diagnostic tool for the imaging of neuroendocrine tumors. This application is based on …

Background: Hypoglycemia in infants and children can lead to seizures, developmental
delay, and permanent brain damage. Hyperinsulinism (HI) is the most common cause of …

Fluoro-(18 F)-L-3, 4-dihydroxyphenylalanine (FDOPA) is an amino acid analogue for
positron emission tomography (PET) imaging which has been registered since 2006 in …

Objectives: Focal lesions in infants with congenital hyperinsulinism (HI) represent areas of
adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation …