Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …

Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …

Cryogenic electron tomography (cryoET) allows visualization of cellular structures in situ.
However, anisotropic resolution arising from the intrinsic “missing-wedge” problem has …

The acquisition of cryo-electron microscopy (cryo-EM) data from biological specimens must
be tightly coupled to data preprocessing to ensure the best data quality and microscope …

After activation by an agonist, G-protein-coupled receptors (GPCRs) recruit β-arrestin, which
desensitizes heterotrimeric G-protein signalling and promotes receptor endocytosis …

Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …

Cryo-electron microscopy (cryo-EM) is rapidly becoming an attractive method in the field of
structural biology. With the exploding popularity of cryo-EM, sample preparation must evolve …

Electron cryo-microscopy analyzes the structure of proteins and protein complexes in
vitrified solution. Proteins tend to adsorb to the air-water interface in unsupported films of …

The organization of genomic DNA into nucleosomes profoundly affects all DNA-related
processes in eukaryotes. The histone chaperone known as 'facilitates chromatin …

Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …