Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and
dietary consumption of these structurally diverse compounds is associated with multiple …

The retina is a multilayer neuronal tissue located in the back of the eye that transduces the
environmental light into a neural impulse. Many eye diseases caused by endogenous or …

Retinitis pigmentosa (RP) is a form of retinal degeneration characterized by primary
degeneration of rod photoreceptors followed by a secondary cone loss that leads to vision …

Photoisomerization of the 11-cis-retinal chromophore of rod and cone visual pigments to an
all-trans-configuration is the initiating event for vision in vertebrates. The regeneration of 11 …

Degeneration of photoreceptors caused by excessive illumination, inherited mutations, or
aging is the principal pathology of blinding diseases. Pharmacological compounds that …

The balanced homeostasis of the G protein–coupled receptor (GPCR), rhodopsin (Rho), is
required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to …

Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans,
against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil …

Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies
that include retinitis pigmentosa and congenital stationary night blindness. Though most of …

Dietary polyphenols are a group of natural compounds that have been proposed to have
beneficial effects on human health. They were first known for their antioxidant properties, but …

Rhodopsin (RHO) mutations are responsible for 25–40% of the dominant cases of retinitis
pigmentosa (RP) with different severity and progression rates. The Tvrm4 mice …