Bronchopulmonary dysplasia

B Thébaud, KN Goss, M Laughon, JA Whitsett… - Nature reviews Disease …, 2019 - nature.com
In the absence of effective interventions to prevent preterm births, improved survival of
infants who are born at the biological limits of viability has relied on advances in perinatal …

Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies

N Principi, GM Di Pietro, S Esposito - Journal of translational medicine, 2018 - Springer
Background Bronchopulmonary dysplasia (BPD) is the result of a complex process in which
several prenatal and/or postnatal factors interfere with lower respiratory tract development …

Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation

GR Willis, A Fernandez-Gonzalez… - American journal of …, 2018 - atsjournals.org
Rationale: Mesenchymal stem/stromal cell (MSC) therapies have shown promise in
preclinical models of pathologies relevant to newborn medicine, such as bronchopulmonary …

MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension

C Lee, SA Mitsialis, M Aslam, SH Vitali, E Vergadi… - Circulation, 2012 - Am Heart Assoc
Background—Hypoxia induces an inflammatory response in the lung manifested by
alternative activation of macrophages with elevation of proinflammatory mediators that are …

The acute respiratory distress syndrome: pathogenesis and treatment

MA Matthay, RL Zemans - Annual Review of Pathology …, 2011 - annualreviews.org
The acute respiratory distress syndrome (ARDS) causes 40% mortality in approximately
200,000 critically ill patients annually in the United States. ARDS is caused by protein-rich …

[HTML][HTML] Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial

YS Chang, SY Ahn, HS Yoo, SI Sung, SJ Choi… - The Journal of …, 2014 - Elsevier
Objective To assess the safety and feasibility of allogeneic human umbilical cord blood
(hUCB)-derived mesenchymal stem cell (MSC) transplantation in preterm infants. Study …

The new bronchopulmonary dysplasia

AH Jobe - Current opinion in pediatrics, 2011 - journals.lww.com
The new bronchopulmonary dysplasia : Current Opinion in Pediatrics The new
bronchopulmonary dysplasia : Current Opinion in Pediatrics Log in or Register Subscribe to …

[HTML][HTML] Caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-κB and A2aR signaling in LPS-Induced THP-1 macrophages

W Zhao, L Ma, C Cai, X Gong - International journal of biological …, 2019 - ncbi.nlm.nih.gov
Excessive inflammation induced by various risk factors is associated with the development
of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a …

Novel aspects of pathogenesis and regeneration mechanisms in COPD

E Bagdonas, J Raudoniute, I Bruzauskaite… - … journal of chronic …, 2015 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD), a major cause of death and morbidity
worldwide, is characterized by expiratory airflow limitation that is not fully reversible …