Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

Protein arginine methyltransferases (PRMTs) play a crucial role in a variety of biological
processes. Overexpression of PRMTs has been implicated in various human diseases …

Growing cancer incidence and mortality worldwide demands development of accurate
biomarkers to perfect detection, diagnosis, prognostication and monitoring. Urologic …

Although therapeutic targets have been developed for colorectal cancer (CRC) therapy, the
therapeutic effects are not ideal and the survival rate for CRC patients remains poor …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Background Accumulating evidence supports that lysine-specific demethylase 5 (KDM5)
family members act as oncogenic drivers. This study was performed to elucidate the …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …