Review of D‐dimer testing: Good, Bad, and Ugly

LA Linkins, S Takach Lapner - International Journal of …, 2017 - Wiley Online Library
D‐dimer assays are commonly used in clinical practice to exclude a diagnosis of deep vein
thrombosis or pulmonary embolism. More recently, they have been also been used to guide …

Clinical decision rules for excluding pulmonary embolism: a meta-analysis

W Lucassen, GJ Geersing, PMG Erkens… - Annals of internal …, 2011 - acpjournals.org
Background: Clinical probability assessment is combined with d-dimer testing to exclude
pulmonary embolism (PE). Purpose: To compare the test characteristics of gestalt (a …

[HTML][HTML] Clinical prediction rules for pulmonary embolism: a systematic review and meta-analysis

E Ceriani, C Combescure, G Le Gal, M Nendaz… - Journal of thrombosis …, 2010 - Elsevier
Background: Pretest probability assessment is necessary to identify patients in whom
pulmonary embolism (PE) can be safely ruled out by a negative D-dimer without further …

Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study

RA Douma, ICM Mos, PMG Erkens… - Annals of internal …, 2011 - acpjournals.org
Background: Several clinical decision rules (CDRs) are available to exclude acute
pulmonary embolism (PE), but they have not been directly compared. Objective: To directly …

Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial

M Righini, G Le Gal, D Aujesky, PM Roy, O Sanchez… - The Lancet, 2008 - thelancet.com
Summary Background Multislice CT (MSCT) combined with D-dimer measurement can
safely exclude pulmonary embolism in patients with a low or intermediate clinical probability …

Diagnostic and prognostic prediction models

JMT Hendriksen, GJ Geersing… - … of Thrombosis and …, 2013 - Wiley Online Library
Risk prediction models can be used to estimate the probability of either having (diagnostic
model) or developing a particular disease or outcome (prognostic model). In clinical …

Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism

FA Klok, ICM Mos, M Nijkeuter, M Righini… - Archives of internal …, 2008 - jamanetwork.com
Background The revised Geneva score is a fully standardized clinical decision rule (CDR) in
the diagnostic workup of patients with suspected pulmonary embolism (PE). The variables of …

[HTML][HTML] Diagnostic management of acute deep vein thrombosis and pulmonary embolism

MV Huisman, FA Klok - Journal of Thrombosis and Haemostasis, 2013 - Elsevier
Acute deep vein thrombosis (DVT) and pulmonary embolism (PE) represent two expressions
of a similar clinical pathological process, often referred to as venous throm-boembolism …

VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism

M Carrier, M Righini, RK Djurabi… - Thrombosis and …, 2009 - thieme-connect.com
Clinical outcome studies have shown that it is safe to withhold anticoagulant therapy in
patients with suspected pulmonary embolism (PE) who have a negative D-dimer result and …

Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study

GJ Geersing, PMG Erkens, WAM Lucassen, HR Büller… - Bmj, 2012 - bmj.com
Objective To validate the use of the Wells clinical decision rule combined with a point of care
D-dimer test to safely exclude pulmonary embolism in primary care. Design Prospective …