Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

Intelligent poly (l-histidine)-based nanovehicles for controlled drug delivery

Y Zhang, I Kim, Y Lu, Y Xu, DG Yu, W Song - Journal of Controlled Release, 2022 - Elsevier
Stimuli-responsive drug delivery systems based on polymeric nanovehicles are among the
most promising treatment regimens for malignant cancers. Such intelligent systems that …

Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery

Y Zhang, W Song, Y Lu, Y Xu, C Wang, DG Yu, I Kim - Biomolecules, 2022 - mdpi.com
Poly (α-L-glutamic acid)(PGA) is a class of synthetic polypeptides composed of the
monomeric unit α-L-glutamic acid. Owing to their biocompatibility, biodegradability, and non …

Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

Y Wu, K Chen, J Wang, M Chen, W Dai… - Journal of the American …, 2024 - ACS Publications
Polypeptides have the same or similar backbone structures as proteins and peptides,
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …

Aqueous ring‐opening polymerization‐induced self‐assembly (ROPISA) of N‐carboxyanhydrides

C Grazon, P Salas‐Ambrosio, E Ibarboure… - Angewandte …, 2020 - Wiley Online Library
Reported here is the first aqueous ring‐opening polymerization (ROP) of N‐
carboxyanhydrides (NCAs) using α‐amino‐poly (ethylene oxide) as a macroinitiator to …

A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

ZY Tian, Z Zhang, S Wang, H Lu - Nature Communications, 2021 - nature.com
A great hurdle in the production of synthetic polypeptides lies in the access of N-
carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe …

Superfast and Water‐Insensitive Polymerization on α‐Amino Acid N‐Carboxyanhydrides to Prepare Polypeptides Using Tetraalkylammonium Carboxylate as the …

Y Wu, K Chen, X Wu, L Liu, W Zhang… - Angewandte …, 2021 - Wiley Online Library
We design the tetraalkylammonium carboxylate‐initiated superfast polymerization on α‐
amino acid N‐carboxyanhydrides (NCA) for efficient synthesis of polypeptides …

Recent Advances and Future Perspectives of Synthetic Polypeptides from N-Carboxyanhydrides

Z Song, Z Tan, J Cheng - Macromolecules, 2019 - ACS Publications
Synthetic polypeptides, the analogues of natural proteins, are important biomaterials that
have found broad biomedical applications. Ring-opening polymerization of N …

Supramolecular peptide nano-assemblies for cancer diagnosis and therapy: from molecular design to material synthesis and function-specific applications

Y Wang, X Zhang, K Wan, N Zhou, G Wei… - Journal of …, 2021 - Springer
Peptide molecule has high bioactivity, good biocompatibility, and excellent biodegradability.
In addition, it has adjustable amino acid structure and sequence, which can be flexible …

Water-assisted and protein-initiated fast and controlled ring-opening polymerization of proline N-carboxyanhydride

Y Hu, ZY Tian, W Xiong, D Wang, R Zhao… - National Science …, 2022 - academic.oup.com
The production of polypeptides via the ring-opening polymerization (ROP) of N-
carboxyanhydride (NCA) is usually conducted under stringent anhydrous conditions. The …