Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease which affects≈
25% of the adult population worldwide, placing a tremendous burden on human health. The …

Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and
sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory …

Cardiovascular diseases are known to be the most fatal diseases worldwide.
Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common …

Background & Aims Tumor necrosis factor receptor-associated factor 1 (TRAF1) is an
important adapter protein that is largely implicated in molecular events regulating …

Neural stem cell (NSC) transplantation is one of the most promising therapeutic strategies
for neurodegenerative diseases. However, the slow spontaneous differentiation of NSCs …

We previously reported the promising effect of dioscin against hepatic ischemia/reperfusion
(I/R) injury, but its effect on cerebral I/R injury remains unknown. In this work, an in vitro …

Present therapies for stroke rest with tissue plasminogen activator (tPA), the sole licensed
antithrombotic on the market; however, tPA's effectiveness is limited in that the drug not only …

The physiological significance of innate immune signaling lies primarily in its role in host
defense against invading pathogens. It is becoming increasingly clear that innate immune …

The innate immune system is an evolutionarily conserved system that senses and defends
against infection and irritation. Innate immune signaling is a complex cascade that quickly …