How can single cells without nervous systems perform complex behaviours such as
habituation, associative learning and decision making, which are considered the hallmark of …

The spatial organization of chromosomes is involved in regulating the majority of
intranuclear processes in higher eukaryotes, including gene expression. Drosophila was …

The field of 3D genome organization produces large amounts of sequencing data from Hi-C
and a rapidly-expanding set of other chromosome conformation protocols (3C+). Massive …

Chromosome conformation capture (3C) technologies reveal the incredible complexity of
genome organization. Maps of increasing size, depth, and resolution are now used to probe …

Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
functional processes, including transcription initiation, the pairwise motion of distal …

Immunocytes dynamically reprogram their gene expression profiles during differentiation
and immunoresponse. However, the underlying mechanism remains elusive. Here, we …

Over the past decade, genome-wide assays for chromatin interactions in single cells have
enabled the study of individual nuclei at unprecedented resolution and throughput. Current …

The mammalian genome possesses> 2000 olfactory receptor (OR) alleles regulated by 63
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …

The three-dimensional (3D) structure of chromosomes influences essential biological
processes such as gene expression, genome replication, and DNA damage repair and has …

Single-cell high-throughput chromatin conformation capture methodologies (scHi-C) enable
profiling of long-range genomic interactions. However, data from these technologies are …