Highlights•Active targeting uses ligands to target drugs to particular tissues or
cells.•Antibodies are commonly used targeting ligands which are bulky and difficult to …

Nucleic acid (NA) therapeutics are a rapidly growing class of biomedicines with the ability to
manipulate gene expression in potent and specific manner, and with the enormous potential …

Combining synthetic polymers with RNA paves the way for creating RNA-based materials
with non-canonical functions. We have developed an acylation reagent that allows for direct …

With the advent of bioconjugation chemistry in the last two decades, highlighted by the
Nobel Prize 2022, the quest for possible novel applications has been greatly intensified …

The self-assembly of block copolymers is often rationalized by structure and microphase
separation; pathways that diverge from this parameter space may provide new mechanisms …

“Clickable” organic electrochemical transistors (OECTs) allow the reliable and
straightforward functionalization of electronic devices through the well-known click chemistry …

In this work, we propose a novel disposable flexible and screen-printed electrochemical
aptamer-based sensor (aptasensor) for the rapid detection of chlorpyrifos (CPF). To optimize …

Neurological disorders present a formidable challenge to modern medicine due to their
complex etiology and limited treatment options. Traditional therapeutic approaches often …

Uniform conjugates combining a DNA aptamer (either anti-MUC1 or ATP aptamer) and a
synthetic polymer segment were synthesized by automated phosphoramidite chemistry. This …

Nucleic acids can modulate gene expression specifically. They are increasingly being
utilized and show huge potential for the prevention or treatment of various diseases …