Psychiatric face of COVID-19

L Steardo Jr, L Steardo, A Verkhratsky - Translational psychiatry, 2020 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) represents a severe multiorgan
pathology which, besides cardio-respiratory manifestations, affects the function of the central …

Immune influencers in action: metabolites and enzymes of the tryptophan-kynurenine metabolic pathway

M Tanaka, F Tóth, H Polyák, Á Szabó, Y Mándi… - Biomedicines, 2021 - mdpi.com
The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …

Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation

B Lima Giacobbo, J Doorduin, HC Klein… - Molecular …, 2019 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Climate change, environment pollution, COVID-19 pandemic and mental health

D Marazziti, P Cianconi, F Mucci, L Foresi… - Science of the total …, 2021 - Elsevier
Converging data would indicate the existence of possible relationships between climate
change, environmental pollution and epidemics/pandemics, such as the current one due to …

[HTML][HTML] Psycho-neuroendocrine-immune interactions in COVID-19: potential impacts on mental health

Í Raony, CS de Figueiredo, P Pandolfo… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2). The impacts of the disease may be beyond the …

Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses

N Yuan, Y Chen, Y Xia, J Dai, C Liu - Translational psychiatry, 2019 - nature.com
Inflammation is a natural defence response of the immune system against environmental
insult, stress and injury, but hyper-and hypo-inflammatory responses can trigger diseases …

Peripheral levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: A meta-analysis of …

M Solmi, MS Sharma, EF Osimo, M Fornaro… - Brain, Behavior, and …, 2021 - Elsevier
Importance It is unclear whether differences exist in the magnitude and variability of pro-
inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects …

[HTML][HTML] Neuroinflammation in bipolar depression

F Benedetti, V Aggio, ML Pratesi, G Greco… - Frontiers in …, 2020 - frontiersin.org
Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders.
Pathological mechanisms are still vastly unclear, and current treatments with conventional …

Inflammation and clinical response to treatment in depression: a meta-analysis

R Strawbridge, D Arnone, A Danese… - European …, 2015 - Elsevier
The depressive state has been characterised as one of elevated inflammation, which holds
promise for better understanding treatment-resistance in affective disorders as well as for …

[HTML][HTML] Cytokine research in depression: principles, challenges, and open questions

H Himmerich, O Patsalos, N Lichtblau… - Frontiers in …, 2019 - frontiersin.org
Cytokines have been implicated in the pathology of depression. Currently, the evidence is
based on cross-sectional studies and meta-analytic research comparing blood …