Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated
with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the …

A number of proteins and nucleic acids have been explored as therapeutic targets. These
targets are subjects of interest in different areas of biomedical and pharmaceutical research …

Many highly proliferative cells generate almost all ATP via glycolysis despite abundant O2
and a normal complement of fully functional mitochondria, a circumstance known as the …

In light of the current rising mean temperatures and fluctuations in temperature extremes
involved in global climate change, a cause-and-effect understanding of the temperature …

Apoptosis is an evolutionary conserved homeostatic process involved in distinct
physiological processes including organ and tissue morphogenesis, development and …

This leading textbook in the field examines the mechanisms underlying toxicity, particularly
the events at the molecular level and the factors that determine and affect toxicity. The new …

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

Diabetes Mellitus (DM), a state of chronic hyperglycemia, is a major cause of serious micro
and macrovascular diseases, affecting, therefore, nearly every system in the body. Growing …