Pore‐forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In
eukaryotes, however, PFTs operate in the immune system or are deployed for attacking prey …

Macrophages are important in the host's immunological and inflammatory responses. There
is a large population of these cells in the normal intestinal mucosa where they represent the …

Macrophages and neutrophils play important roles during the innate immune response,
phagocytosing invading microbes and delivering antimicrobial compounds to the site of …

Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal
cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the …

Impaired wound healing associated with recurrent Staphylococcus aureus infection and
unresolved inflammation are hallmarks of nonhealing diabetic foot ulcers (DFUs). Perforin-2 …

Phagosomes are key organelles for the innate ability of macrophages to participate in tissue
remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To …

α-N-Acetylglucosaminidase deficiency (mucopolysaccharidosis IIIB, MPS IIIB) and α-l-
iduronidase deficiency (MPS I) are heritable lysosomal storage diseases; …

The era of targeted therapies has seen significant improvements in depth of response,
progression-free survival, and overall survival for patients with multiple myeloma. Despite …

Sandhoff disease is a lysosomal storage disorder characterized by the absence of β-
hexosaminidase and storage of GM2 ganglioside and related glycolipids in the central …

Abstract The Spi1/Pu. 1 transcription factor plays a crucial role in myeloid cell development
in vertebrates. Despite extensive studies of Spi1, the controlled gene group remains largely …