Vigilant attention is a major component of a wide range of cognitive performance tasks.
Vigilant attention is impaired by sleep deprivation and restored after rest breaks and (more …

Sleep function remains controversial. Individual perspectives frame the issue of sleep
function differently. We briefly illustrate how sleep measurement and the evolution, tissue …

Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa.
Sleep-inducing inflammatory molecules are activated by increased waking activity and …

Sleep is a complex physiological process that is regulated globally, regionally, and locally
by both cellular and molecular mechanisms. It occurs to some extent in all animals, although …

The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

Microglia, the brain's resident macrophages, actively contribute to the homeostasis of
cerebral parenchyma by sensing neuronal activity and supporting synaptic remodeling and …

Symptoms commonly associated with sleep loss and chronic inflammation include
sleepiness, fatigue, poor cognition, enhanced sensitivity to pain and kindling stimuli, excess …

Astrocytes mediate many important aspects of neural homeostasis, but until recently, their
role in sleep was largely unknown. The situation has dramatically changed in the last …