Depression is the most common psychiatric disease among women, exhibiting a prevalence
which is 2–3× higher than in men. The postpartum period is considered the time of greatest …

A great number of clinical observations show a relationship between epilepsy and
depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic …

Berberine, an alkaloid isolated from Berberis aristata Linn. has been used in the Indian
system of medicines as a stomachic, bitter tonic, antiamoebic and also in the treatment of …

Rationale Chronic social defeat stress (CSDS) has been proposed as a model of
depression. However, most CSDS studies rely only on the analysis of stress-induced social …

Honokiol and magnolol are the main constituents simultaneously identified in the barks of
Magnolia officinalis, which have been used in traditional Chinese medicine to treat a variety …

Background We investigated the effects of liraglutide, a glucagon-like peptide-1 (GLP-1)
agonist, on a depression-like phenotype in mice exposed to chronic unpredictable stress …

Gene microarrays may enable the elucidation of neurobiological changes underlying the
pathophysiology and treatment of major depression. However, previous studies of …

Oxidative stress is a critical route of damage in various psychological stress-induced
disorders, such as depression. Antidepressants are widely prescribed to treat these …

Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in
the pathophysiology of major depression, but little is known regarding the causal link …

Major depression (MD) is one of the most common psychiatric disorders worldwide.
Currently, the first-line treatment for MD targets the serotonin system but these drugs, notably …