Objective: To attempt to determine the relative value of preclinical cardiac electrophysiology
data (in vitro and in vivo) for predicting risk of torsade de pointes (TdP) in clinical use …

This review addresses novel concepts of histamine H1‐receptor function and attempts to
relate them to the anti‐inflammatory effects of H1‐antihistamines. Furthermore, the …

Luminescence imaging has gained attention as a promising bio-imaging modality in
situations where fluorescence imaging cannot be applied. However, wider application to …

Broad-scale in vitro pharmacology profiling of new chemical entities during early phases of
drug discovery has recently become an essential tool to predict clinical adverse effects …

In this paper, we present a pharmacophore for QT-prolonging drugs, along with a 3D QSAR
(CoMFA) study for a series of very structurally variegate HERG K+ channel blockers. The …

Prolongation of the QT interval of the electrocardiogram is a typical effect of Class III
antiarrhythmic drugs, achieved through blockade of potassium channels. In the past decade …

The long and growing list of non-antiarrhythmic drugs associated with prolongation of the QT
interval of the electrocardiogram has generated concern not only for regulatory interventions …

Chronic urticaria is a common condition that can be very disabling when severe. A cause for
chronic idiopathic urticaria (CIU) is only infrequently identified. Potential causes include …

A variety of drugs targeted towards the central nervous system are associated with cardiac
side effects, some of which are linked with reports of arrhythmia and sudden death. Some …

Background: Evidence has accrued that several non-cardiac drugs may prolong cardiac
repolarisation (hence, the QT interval of the surface electrocardiogram) to such a degree that …