Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

R ECENT studies suggest that pro teases of the inter leukin 1-β-con-verting enzyme
(ICE)/ced-3 family are involved in initiating the active phase of apoptosis1–3. Here we …

We have found that the mammalian Ran GTPase–activating protein RanGAP1 is highly
concentrated at the cytoplasmic periphery of the nuclear pore complex (NPC), where it …

Ran is a nuclear Ras-like GTPase that is required for the bidirectional transport of proteins
and ribnucleoproteins across the nuclear pore complex (NPC). A key regulator of the Ran …

GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and
action. Their functions depend on their ability to alternate between inactive and active forms …

TAR DNA-binding protein 43 (TDP-43) is the disease protein in frontotemporal lobar
degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis …

THE product of the gene RCC1 (regulator of chromosome condensation) in a BHK cell line
is involved in the control of mitotic events1. Homologous genes have been found in …

Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is
mediated by a superfamily of transport receptors known collectively as karyopherins …

Abstract Amyotrophic lateral sclerosis 2 (ALS2) is an autosomal recessive form of juvenile
ALS and has been mapped to human chromosome 2q33. Here we report the identification of …